Sponsor
This work was supported by the National Institutes of Health (SC2-GM113727 and F32-GM090492 to J.A.R., R01- GM087628 to D.R.D. and S.E.); and the National Science Foundation (MCB-1330427 to S.E. and D.R.D.).
Published In
Molecular Biology and Evolution
Document Type
Article
Publication Date
9-2016
Subjects
Caenorhabditis, Mitochondrial DNA, Variation (Biology)
Abstract
To study mitochondrial-nuclear genetic interactions in the nematode Caenorhabditis briggsae, our three laboratories independently created 38 intra-species cytoplasmic-nuclear hybrid (cybrid) lines. Although the cross design combines maternal mitotypes with paternal nuclear genotypes, eight lines (21%) unexpectedly contained paternal mitotypes. All eight share in common ancestry of one of two genetically related strains. This unexpected parallel observation of paternal mitochondrial transmission, undesirable given our intent of creating cybrids, provides a serendipitous experimental model and framework to study the molecular and evolutionary basis of uniparental mitochondrial inheritance.
DOI
10.1093/molbev/msw192
Persistent Identifier
http://archives.pdx.edu/ds/psu/18369
Citation Details
Ross JA, Howe DK, Coleman-Hulbert A, Denver DR, Estes S. (2016). Paternal Mitochondrial Transmission in Intra-Species Caenorhabditis briggsae Hybrids. Molecular Biology and Evolution.
Supplementary Data
Description
© The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Supplementary figure S1 is available below in the Additional Files