This research was funded by National Institutes of Health grant R01 EY014594 (to A. Eisner) and by an unrestricted grant to the Casey Eye Institute from Research to Prevent Blindness (New York, N.Y.)
Optical tomography -- Technological innovations, Optical coherence tomography, Retina
Purpose—This study tested a prediction stemming from the hypothesis that anastrozole users experience heightened vitreo-retinal traction. This hypothesis was based on the knowledge that menopause increases the risk of intraocular tractional events such as posterior vitreous detachments (PVDs).
Methods—Retinal thickness was measured for 3 groups of amenorrheic women: (1) anastrozole users and (2) tamoxifen users undergoing adjuvant therapy for early-stage breast cancer, and (3) control subjects not using hormonal medication. Foveal shape indices were derived for subjects without PVDs.
Results—For anastrozole users, the distance to the temporal side of the fovea became less than the distance to the nasal side at a sufficient height above the foveal base. This effect did not exist for control subjects; the between-group difference was appreciable. Results concerning tamoxifen users were inconclusive.
Conclusions—The foveas of women using anastrozole appear to be subjected to more tractional force than are the foveas of women not using any hormonal medication.
Eisner, Alvin; Thielman, Emily J.; Falardeau, Julie; and Vetto, John T., "Vitreo-Retinal Traction and Anastrozole Use" (2009). Community Health Faculty Publications and Presentations. 59.