Assessment of Oxygen Saturation in Retinal Vessels of Normal Subjects and Diabetic Patients with and without Retinopathy using Flow Oximetry System
The study is supported in part by a grant from the National Eye Institute, National Institutes of Health (RO1 EY017577 for QDN).
Quantitative Imaging in Medicine and Surgery
Oxygen -- Physiological transport -- Measurement, Diabetes -- Effect on retinal vessels, Oximetry
Purpose: To assess oxygen saturation (StO2) in retinal vessels of normal subjects and diabetic patients with and without retinopathy using the modified version of the Flow Oximetry System (FOS) and a novel assessment software.
Methods: The FOS and novel assessment software were used to determine StO2 levels in arteries and veins located between 1 and 2 mm from the margin of the optic disc and in the macular area.
Results: Eighteen normal subjects, 15 diabetics without diabetic retinopathy (DM no DR), and 11 with non-proliferative diabetic retinopathy (NPDR) were included in final analysis. The mean [± standard deviation (SD)] StO2 in retinal arteries was 96.9%±3.8% in normal subjects; 97.4%±3.7% in DM no DR; and 98.4%±2.0% in NPDR. The mean venous StO2 was 57.5%±6.8% in normal subjects; 57.4%±7.5% in DM no DR; and 51.8%±6.8% in NPDR. The mean arterial and venous StO2 across the three groups were not statistically different (P=0.498 and P=0.071, respectively). The arterio-venous differences between the three study groups, however, were found to be statistically significant (P=0.015). Pairwise comparisons have demonstrated significant differences when comparing the A-V difference in the NPDR group to either normal subjects (P=0.02) or diabetic patients without DR (P=0.04).
Conclusions: The arterio-venous difference was greater, and statistically significant, in patients with NPDR when compared to normal subjects and to patients with diabetes and no retinopathy. The mean venous StO2 was lower, but not statistically significant, in NPDR compared with diabetics without retinopathy and with normal subjects.
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Unaffiliated researchers can access the work here: http://dx.doi.org/10.3978/j.issn.2223-4292.2014.11.26
Ibrahim, M. A., Annam, R. E., Sepah, Y. J., Luu, L., Bittencourt, M. G., Jang, H. S., ... & Nguyen, Q. D. (2015). Assessment of oxygen saturation in retinal vessels of normal subjects and diabetic patients with and without retinopathy using Flow Oximetry System. Quantitative imaging in medicine and surgery, 5(1), 86.