First Advisor
Suzanne R. Estes
Date of Award
1-1-2012
Document Type
Thesis
Degree Name
Bachelor of Science (B.S.) in Biology and University Honors
Department
Biology
Language
English
Subjects
DNA repair, Mitochondrial DNA
DOI
10.15760/honors.10
Abstract
In this present study, I use C. elegans as a model organism to better characterize the phenotypic response to deficiencies in base excision repair (BER). This will help to elucidate how DNA damage, increased mutagenesis, and exposure to reactive oxygen species (ROS) is related to Metabolic Syndrome. Additionally, this work will establish a starting point for investigation that can further characterize phenotypic responses such as mitochondrial physiology and morphology through measurements of mitochondrial membrane potential and mitochondrial circularity. The overall goal of this research is to better understand the nature of mitochondrial dysfunction with respect to the inactivation of DNA glycosylases, as well as understand the contribution DNA repair processes have to the maintenance of energy homeostasis and substrate oxidation.
Rights
In Copyright. URI: http://rightsstatements.org/vocab/InC/1.0/ This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
Persistent Identifier
http://archives.pdx.edu/ds/psu/9330
Recommended Citation
Hase, Travis Lee, "In Vivo Quantification of Reactive Oxygen Species Demonstrates High Levels of Oxidative Stress in Base Excision Repair-Deficient Caenorhabditis Elegans: Implications for Associative Metabolic Phenotypes" (2012). University Honors Theses. Paper 10.
https://doi.org/10.15760/honors.10