Date of Award

2017

Document Type

Thesis

Department

Biology

First Advisor

Alexey Danilov

Subjects

Lymphocytes -- Metabolism, Apoptosis, Leukemia, B cells -- Receptors

DOI

10.15760/honors.407

Abstract

Malignant B-cell lymphocytes in chronic lymphocytic leukemia are supported by a network of survival signals from the bone marrow and lymph node microenvironments. These induce resistance to existing therapies such as inhibitors of B-cell receptor (BCR)-associated kinases, possibly due to the circumvention of BCRs to induce the same survival responses. It has been demonstrated that downstream responses to BCR stimulation can be induced through B-cell activating factor (BAFF) stimulation. Here, a mechanism for this pathway is proposed.

Comments

An undergraduate honors thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in University Honors and Biology.

Persistent Identifier

http://archives.pdx.edu/ds/psu/20402

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