PSU McNair Scholars Online Journal

Article Title

The Synthesis and Characterization of SNAFR‐5 Derivatives


The synthesis and characterization of a new series of long wavelength and NIR-active dyes for use as diagnostic indicators in biological fluids has been carried out. The dyes are synthesized by a one-pot acid promoted condensation and isolated by flash column chromatography. Their structures are assigned by NMR and mass spectrometry. The spectral properties are evaluated by UV-vis and fluorescence spectroscopy. Preliminary spectroscopic data reveal these dyes exhibit anticipated characteristics that apparently meet the current requirements as NIR-active dye candidates for bioimaging and medical applications.

Faculty Mentor: Dr. Robert M. Strongin