This work was supported by Portland State University and National Science Foundation Research Grant 1243963 (to K.M.S. and M.C.M.) and Grant 0702020 to K.M.S.
Virology research, Archaebacteria -- Host-virus relationships, Thermophilic microorganisms, Biology, Genomics, Microbiology
The structure and assembly of many icosahedral and helical viruses are well-characterized. However, the molecular basis for the unique spindle-shaped morphology of many viruses that infect Archaea remains unknown. To understand the architecture and assembly of these viruses, the spindle-shaped virus SSV1 was examined using cryo-EM, providing the ﬁrst 3D-structure of a spindle-shaped virus as well as insight into SSV1 biology, assembly and evolution. Furthermore, a geometric framework underlying the distinct spindle-shaped structure is proposed.
Kenneth M. Stedman, Melissa DeYoung, Mitul Saha, Michael B. Sherman, Marc C. Morais, Structural insights into the architecture of the hyperthermophilic Fusellovirus SSV1, Virology, Volume 474, 1 January 2015, Pages 105-109, ISSN 0042-6822, http://dx.doi.org/10.1016/j.virol.2014.10.014.