James F. Pankow
Date of Award
Master of Science (M.S.) in Civil & Environmental Engineering
Civil and Environmental Engineering
Tobacco smoke -- Composition, Tobacco -- Composition, Tobacco smoke pollution -- Measurement, Tobacco smoke -- Analysis
The acid/base chemistry of cigarette smoke allows nicotine, the primary drug in mainstream tobacco smoke, to exist in protonated and free-base forms. Evidence suggests that most of the nicotine present in mainstream tobacco smoke is in the particle phase. αfb is the fraction of particle-phase nicotine in the free-base form. The magnitude and rate of nicotine deposition in the respiratory tract is dependent on αfb because only the free-base form of nicotine can volatilize from the particle phase of an inhaled aerosol and, once gaseous, rapidly deposit. This study develops a headspace solid-phase microextraction technique coupled with gas chromatography/mass spectrometry analysis that effectively quantifies αfb. The developed method is used to study the αfb of several commercial cigarette brands. This research has important implications on the drug delivery rate and addiction potential of inhaled mainstream tobacco smoke particulate matter.
Motti, Christopher S., "Analyzing Free-Base Nicotine Content in the Particulate Matter of Mainstream Tobacco Smoke Using a Headpace Solid-Phase Microextraction GC/MS Method" (2015). Civil and Environmental Engineering Master's Project Reports. 16.