Published In

Organic Letters

Document Type

Post-Print

Publication Date

12-30-2016

Subjects

cysteine, Homocysteine, Fluorescent probes -- Design and construction, Thiols, Fluorescent probes -- Effect of pH on

Abstract

The very close structural similarities between cysteine and homocysteine present a great challenge to achieve their selective detection using regular fluorescent probes, limiting the biological and pathological studies of these two amino thiols. A coumarin-based fluorescent probe was designed featuring pH-promoted distinct turn-on followed by ratiometric fluorescence responses for Cys and turn-on fluorescence response for Hcy through two different reaction paths. These specific responses demonstrate the activity differences between Cys and Hcy qualitatively for the first time. The probe could also be used for Cys and Hcy imaging in living cells.

Description

This is the author accepted manuscript of an article published by the American Chemical Society.

https://doi/org/10.1021/acs.orglett.6b03357

DOI

10.1021/acs.orglett.6b03357

Persistent Identifier

http://archives.pdx.edu/ds/psu/23556

Available for download on Thursday, February 07, 2019

Included in

Chemistry Commons

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