Title

Detecting Intracellular ClO- with Ratiometric Fluorescent Signal and its Application in Civo

Published In

Sensors and Actuators B: Chemical

Document Type

Citation

Publication Date

11-2018

Abstract

BODIPY and coumarin were assembled into a single scaffold that was cleaved upon oxidation by ClO-, thereby enabling ratiometric fluorescent detection ClO−. The ratiometric fluorescence response was distinctive (|510/|660=18.3) in the presence of ClO-. It was accompanied by an obvious solution color change from dark-blue to colorless. The probe is highly selective and sensitive towards ClO-, with a rapidly response time. Moreover, imaging experiments in live HeLa cells showed that the probe could readily penetrate the cell membrane and was amenable to real-time imaging of ex/endogenous ClO-. Importanty, the probe was successfully used to detect ClO- in vivo via imaging an arthritis nude mouse model.

Description

© 2018 Elsevier B.V. All rights reserved.

DOI

10.1016/j.snb.2018.07.072

Persistent Identifier

https://archives.pdx.edu/ds/psu/26986

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