We thank the NIH and the FDA for their support via award R01ES025257. Content is solely the responsibility of the authors and does not necessarily represent the views of the NIH or the FDA. We would like to acknowledge NSF grant #0741993 for the HPLC-ESIMS data collection. We would like to thank the laboratory of Dr. James Pankow for assistance with acquiring GCMS data.
Pine rosin -- Toxicity, Cannabis extracts -- Additives -- Analysis, Vaping -- Health aspects, EVALI
Pine rosin (colophony) has been identified as a new adulterant in cannabis oil. Its inhalation toxicity poses a significant health concern to users. For example, pine rosin fumes are released during soldering, and have been cited as a causative agent of occupational asthma. Symptoms also include desquamation of bronchial epithelium, which has also been observed in EVALI patients. The sample analyzed herein was acquired from a cannabis industry source, also contains medium chain triglycerides and oleamide, the latter of which is a hypnotic that is commonly found in the synthetic marijuana product Spice, or K2. A combination of NMR and HPLC-ESIMS was used to unambiguously identify major pine rosin ingredients such as abietic and other resin acids. Comparison to commercial samples of pure pine rosin confirmed the assignment.
Meehan-Atrash, Jiries; Strongin, Robert (2020): Pine Rosin as a Toxic Cannabis Extract Adulterant. ChemRxiv. Preprint. https://doi.org/10.26434/chemrxiv.11634303.v1