Title

Lanthanide Metal-Organic Frameworks for Multispectral Radioluminescent Imaging

Published In

Acs Applied Materials & Interfaces

Document Type

Citation

Publication Date

6-17-2020

Abstract

In this report, we describe the X-ray luminescent properties of two lanthanide-based nanoscale metal–frameworks (nMOFs) and their potential as novel platforms for optical molecular imaging techniques such as X-ray excited radioluminescence (RL) imaging. Upon X-ray irradiation, the nMOFs display sharp tunable emission peaks that span the visible to near-infrared spectral region (∼400–700 nm) based on the identity of the metal (Eu, Tb, or Eu/Tb). Surface modification of the nMOFs with polyethylene glycol (PEG) resulted in nanoparticles with enhanced aqueous stability that demonstrated both cyto- and hemo-compatibility important prerequisites for biological applications. Importantly, this is the first report to document and investigate the radioluminescent properties of lanthanide nMOFs. Taken together, the observed radioluminescent properties and low in vitro toxicity demonstrated by the nMOFs render them promising candidates for in vivo translation.

Description

© 2020 American Chemical Society

DOI

10.1021/acsami.0c06010

Persistent Identifier

https://archives.pdx.edu/ds/psu/33970

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