Sponsor
The authors acknowledge support from the Alfred P. Sloan Foundation Matter-to-Life program Grant number G-2021-16944 (J.D., C.W.C., and P.R.W.), the Canadian Institutes of Health Research and Natural Sciences and Engineering Research Council of Canada (H.C.), the Academy of Finland and Sigrid Juselius Foundation (H.T.), and a Royal Society Newton International Fellowship (C.A.C.). Most AlphaFold structures were generated by the New Zealand eScience Infrastructure (NeSI) high performance computing facilities, funded jointly by NeSI's collaborator institutions and the Ministry of Business, Innovation & Employment's Research Infrastructure programme. Open access publishing facilitated by The University of Auckland, as part of the Wiley - The University of Auckland agreement via the Council of Australian University Librarians.
Published In
Iubmb Life
Document Type
Article
Publication Date
12-1-2024
Subjects
RNA -- analysis, Gene expression, RNA, Ribosomes
Abstract
The aminoacyl-tRNA synthetases (aaRS) are a large group of enzymes that implement the genetic code in all known biological systems. They attach amino acids to their cognate tRNAs, moonlight in various translational and non-translational activities beyond aminoacylation, and are linked to many genetic disorders. The aaRS have a subtle ontology characterized by structural and functional idiosyncrasies that vary from organism to organism, and protein to protein. Across the tree of life, the 22 coded amino acids are handled by 16 evolutionary families of Class I aaRS and 21 families of Class II aaRS. We introduce AARS Online, an interactive Wikipedia-like tool curated by an international consortium of field experts. This platform systematizes existing knowledge about the aaRS by showcasing a taxonomically diverse selection of aaRS sequences and structures. Through its graphical user interface, AARS Online facilitates a seamless exploration between protein sequence and structure, providing a friendly introduction to the material for non-experts and a useful resource for experts. Curated multiple sequence alignments can be extracted for downstream analyses. Accessible at www.aars.online, AARS Online is a free resource to delve into the world of the aaRS.
Rights
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2024 The Author(s). IUBMB Life published by Wiley Periodicals LLC on behalf of International Union of Biochemistry and Molecular Biology
Locate the Document
DOI
10.1002/iub.2911
Persistent Identifier
https://archives.pdx.edu/ds/psu/42997
Citation Details
Douglas, J., Cui, H., Perona, J. J., Vargas‐Rodriguez, O., Tyynismaa, H., Carreño, C. A., Ling, J., Ribas de Pouplana, L., Yang, X., Ibba, M., Becker, H., Fischer, F., Sissler, M., Carter, C. W., & Wills, P. R. (2024). AARS Online: A collaborative database on the structure, function, and evolution of the aminoacyl‐tRNA synthetases. IUBMB Life, 76(12), 1091–1105. Portico.