Support from the National Institutes of Health via award RO1 EB002044 is gratefully acknowledged
Supramolecular chemistry, Cysteine -- Detection, Fluorescent probes
A new fluorogenic fluorescein derivative containing an α,β-unsaturated aldehyde moiety produces a selective fluorescent signal enhancement in the presence of cysteine or peptides containing N-terminal cysteine residues. The mechanism is based on synergistic covalent and supramolecular interactions.
Lim, Soojin; Escobedo, Jorge O.; Lowry, Mark; Xu, Xiangyang; and Strongin, Robert M., "Selective Fluorescence Detection of Cysteine and N-Terminal Cysteine Peptide Residues" (2010). Chemistry Faculty Publications and Presentations. 54.