Document Type


Publication Date



Optical tomography -- Technological innovations, Optical coherence tomography, Retina


Purpose—This study tested a prediction stemming from the hypothesis that anastrozole users experience heightened vitreo-retinal traction. This hypothesis was based on the knowledge that menopause increases the risk of intraocular tractional events such as posterior vitreous detachments (PVDs).

Methods—Retinal thickness was measured for 3 groups of amenorrheic women: (1) anastrozole users and (2) tamoxifen users undergoing adjuvant therapy for early-stage breast cancer, and (3) control subjects not using hormonal medication. Foveal shape indices were derived for subjects without PVDs.

Results—For anastrozole users, the distance to the temporal side of the fovea became less than the distance to the nasal side at a sufficient height above the foveal base. This effect did not exist for control subjects; the between-group difference was appreciable. Results concerning tamoxifen users were inconclusive.

Conclusions—The foveas of women using anastrozole appear to be subjected to more tractional force than are the foveas of women not using any hormonal medication.


This is the author’s version of a work that was accepted for publication in Breast Cancer Research and Treatment. Changes resulting from the publishing process, such as editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Breast Cancer Research and Treatment. 2009 September ; 117(1): 9–16.

* At the time of publication Alvin Eisner was affiliated with Oregon Health & Science University



Persistent Identifier

Included in

Ophthalmology Commons