Published In
Environmental Epidemiology
Document Type
Article
Publication Date
2020
Subjects
Air -- Pollution -- Environmental aspects, Air quality management
Abstract
Background:
To examine whether neighborhood deprivation modifies the association between early life air pollution exposure and autism spectrum disorder (ASD), we used resources from a multisite case–control study, the Study to Explore Early Development.
Methods:
Cases were 674 children with confirmed ASD born in 2003–2006; controls were 855 randomly sampled children born during the same time period and residents of the same geographic areas as cases. Air pollution was assessed by roadway proximity and particulate matter
Results:
Neighborhood deprivation modified (Pfor interaction = 0.08) the association between PM2.5 exposure during the first year of life and ASD, with a stronger association for those living in high (OR = 2.42, 95% CI = 1.20, 4.86) rather than moderate (OR=1.21, 95% CI = 0.67, 2.17) or low (OR=1.46, 95% CI = 0.80, 2.65) deprivation neighborhoods. Departure from additivity or multiplicativity was not observed for roadway proximity or exposures during pregnancy.
Conclusion:
These results provide suggestive evidence of interaction between neighborhood deprivation and PM2.5 exposure during the first year of life in association with ASD.
Locate the Document
DOI
10.1097/EE9.0000000000000067
Persistent Identifier
https://archives.pdx.edu/ds/psu/33251
Citation Details
McGuinn, L. A., Windham, G. C., Messer, L. C., Di, Q., Schwartz, J., Croen, L. A., ... & Gammon, M. D. (2019). Air pollution, neighborhood deprivation, and autism spectrum disorder in the Study to Explore Early Development. Environmental Epidemiology, 3(5), e067.
Description
© 2020 by the authors. Licensee: Wolters Kluwer. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).