First Advisor

Suzanne R. Estes

Date of Award

1-1-2012

Document Type

Thesis

Degree Name

Bachelor of Science (B.S.) in Biology and University Honors

Department

Biology

Subjects

DNA repair, Mitochondrial DNA

DOI

10.15760/honors.10

Abstract

In this present study, I use C. elegans as a model organism to better characterize the phenotypic response to deficiencies in base excision repair (BER). This will help to elucidate how DNA damage, increased mutagenesis, and exposure to reactive oxygen species (ROS) is related to Metabolic Syndrome. Additionally, this work will establish a starting point for investigation that can further characterize phenotypic responses such as mitochondrial physiology and morphology through measurements of mitochondrial membrane potential and mitochondrial circularity. The overall goal of this research is to better understand the nature of mitochondrial dysfunction with respect to the inactivation of DNA glycosylases, as well as understand the contribution DNA repair processes have to the maintenance of energy homeostasis and substrate oxidation.

Rights

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Persistent Identifier

http://archives.pdx.edu/ds/psu/9330

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