Date of Award
Bachelor of Science (B.S.) in Biology and University Honors
Poly Cystic Ovary Syndrome and Pelvic Floor Dysfunction are reproductive diseases with comorbidities whose novel relationship deserves further investigation.
Levator Ani Muscle/Paravaginal Attachment was dissected from female Rhesus Macaque and subjected to tissue dissociation. Cells were treated with serum level hormones E2, T, and DHT. PCR, ICC, and IHC were used, followed by statistical analysis.
RNA analysis show differences in relative expression for endpoints ER, PR, AR, Ki-67, Col1A, and Vimentin. IHC along with ICC showed expression and localization in vivo.
A novel in vitro model was created from macaque Levator Ani Muscle/Paravaginal Attachment for Pelvic Floor Dysfunction in Poly Cystic Ovary Syndrome women. Treatment of cells with androgens revealed a potential therapeutic target and possible etiology of PFD in PCOS women.
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Vila, Ruben, "A Novel in vitro Method for Pelvic Floor Dysfunction in PCOS Women" (2021). University Honors Theses. Paper 1076.