First Advisor

Mark Woods

Date of Award


Document Type


Degree Name

Bachelor of Science (B.S.) in Biochemistry and University Honors




Bismuth compounds -- Synthesis, Contrast media (Diagnostic imaging), Bismuth compounds -- Diagnostic use, Nanostructured materials




Medical imaging now plays an integral role in the diagnosis and treatment of illness. The use of contrast agents in molecular imaging has been instrumental in the diagnosis of cancer and similar pathologies. The incorporation of lanthanide-based contrast agents employed in magnetic resonance imaging (MRI) into nano-assembled capsules (NACs) have shown potential utility for improved contrast in MRI by slowing the tumbling of the polyanionic paramagnetic metal ions. The utility of NACs was herein extended to computed tomography (CT) imaging by the incorporation of electron dense bismuth (III)-based chelates into NACs in order to provide a high payload of agent in relatively small volumes. Bismuth (III) was chelated with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylene phosphonate (DOTP) and incorporated into a NAC encapsulated with a spherical silica nanoparticle shell at varied concentrations, solvent systems and temperature. The size distribution of these NACs was characterized and compared to gadolinium-based NACs. The formation of bismuth containing NACs was confirmed; the reproducibility in size distribution was not as reproducible as expected, and did not adhere to the same trends as lanthanide containing capsules. Although aging time may be directly related to size distribution of the capsules, the solvent system and temperature studies did not yield a consistent relationship.


In Copyright. URI: This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).

Persistent Identifier