Date of Award
RNA, Genetic recombination, Game theory, Molecular dynamics
Origins of life research requires searching for a plausible transition from simple chemicals to larger macromolecules that can both hold information and catalyze their own production. It has been shown that some classes of RNA molecules possess the ability to help other RNA molecules form by recombination reactions in an auto-catalytic fashion.1 By simplifying these recombination reactions, the thermodynamic binding strength between two nucleotides of two molecules can be quantified for all 16 possible genotype combinations. The purpose of this research is to provide evidence that the thermodynamic binding strength between the tag and internal guide sequence (IGS) is correlated to the catalytic ability of the ribozyme, or the specific relationship between various tag and IGS base pair combinations.
Satterwhite, Elizabeth, "Ribozyme/Duplex Binding Interactions as a Thermodynamic Basis for Chemical Game Theory" (2016). University Honors Theses. Paper 308.