First Advisor

Claire Wheeler

Date of Award


Document Type


Degree Name

Bachelor of Science (B.S.) in Health Studies: Health Sciences and University Honors


Health Studies


Mycobacterial diseases -- Patients -- Psychology, Lungs -- Diseases -- Patients -- Psychology, Depression, Mental -- Diagnosis, Anxiety disorders -- Diagnosis




Previous work has shown that elderly women with chronic or infectious disease are at an especially high risk for mental health disorders such as depression and anxiety. Although, Nontuberculous mycobacterium (NTM) is a common lung disease in Oregon, little research has been published on fundamental epidemiological measures such as prevalence, or incidence, populations risks, and disease comorbidities. The objective of the study is to build a rationale for screening for anxiety and depression in NTM patients through a review of current literature of other lung diseases. Additionally, this project includes a chart review that shows the proportion of patients with NTM who lack history of mental health diagnosis or medication prescription, but have high scores on the Patient Health Questionnaire (PHQ-8) and/or Generalized Anxiety Disorder (GAD-7), reflecting potentially significant symptomology of either depression, anxiety, or both. A cutoff score for "positive" vs. "negative" presence of each disorder was established, based on prior studies using these scales. Questionnaire data have been accumulated on patients in the study. These data were gathered, originally, for a larger biobank study by OHSU's Center for Infectious Disease team. In addition to the screening results, data regarding the patients' anxiety and/or depression diagnosis history and psychotherapeutic medication prescription history has been included in analysis. This has been done through a chart review of the patients' electronic medical records using the Epic system. Statistical analysis using a chi-square has helped ascertain if the prevalence of patients who show symptoms, but no intervention is significantly higher than in those who do not. For both depression and anxiety there is a statistically significant relationship (p < 0.05 and p < 0.001 respectively) between screening score and the presence of a diagnosis/medication. Most participants who screened positive had both a diagnosis and took medications or they had neither. With these data I provide a recommendation that once patients are found positive for NTM, providers should screen for both depression and anxiety regardless of mental health history.


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