First Advisor

Shankar Rananavare

Date of Award

5-22-2020

Document Type

Thesis

Degree Name

Bachelor of Science (B.S.) in Chemistry: Biochemistry and University Honors

Department

Biochemistry

Language

English

Subjects

Anti-microbial agents, Cell death -- Effect of copper ions on, Copper -- Toxicity -- Effect of cysteine on, Escherichia coli

DOI

10.15760/honors.860

Abstract

The antimicrobial properties of copper have been thoroughly researched, but is still unclear what the actual mechanism of cell death is. This study explores the theory that copper ions and other copper sources act as an antibiotic for E. coli by cleaving the disulfide bonds of membrane proteins through redox chemistry, disrupting the cell membrane and causing cell death. The focus of this study is Cu(I) and Cu(II) interactions with the thiol containing amino acid, cysteine, and how these interactions may be responsible for copper’s toxicity. Cuprous ions have been found to be more toxic to E.coli than cupric ions. The difference between cysteine’s reactions with Cu(I) and Cu(II) are explored.

Rights

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Persistent Identifier

https://archives.pdx.edu/ds/psu/33026

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