First Advisor

Gaurav Sahay

Date of Award

5-22-2020

Document Type

Thesis

Degree Name

Bachelor of Science (B.S.) in Computer Science and University Honors

Department

Computer Science

Language

English

Subjects

Myc oncogenes, Transcription factors, Proto-oncogenes, Cancer -- Etiology, Genetic regulation

DOI

10.15760/honors.895

Abstract

A systematic review of the available studies on the interference of OmoMyc with Myc’s function in cancerous cells is presented. Myc is a transcription factor that regulates cellular processes such as apoptosis, proliferation, and differentiation. However, Myc is often overexpressed in a variety of cancers, resulting in abnormal growth of cancer cells. Although the inhibition of Myc has been highly desired, it remained a challenge due to its undruggable characteristics. Attempts to inhibit Myc have involved the usage of small-molecules, but these attempts have failed, causing adverse effects and incomplete inhibition of Myc. Despite promising preclinical studies of OmoMyc, it is only considered as a proof of principle due to the difficulties to deliver into cells. The results of this systematic review are discussed in hopes of overcoming difficulties in the delivery of OmoMyc in vitro transcribed mRNA (IVT-mRNA) in efforts to inhibit the overexpression of Myc.

Rights

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Persistent Identifier

https://archives.pdx.edu/ds/psu/33144

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