Title

EL20, A Potent Antiarrhythmic Compound, Selectively Inhibits Calmodulin-Deficient Ryanodine Receptor Type 2

Published In

Heart Rhythm

Document Type

Citation

Publication Date

4-1-2018

Abstract

This work provides a potential therapeutic mechanism for the development of antiarrhythmic compounds that inhibit leaky RyR2 resulting from CaM dissociation, which is often associated with failing hearts. Our data also suggest that CaM dissociation may contribute to the pathogenesis of arrhythmias with the CPVT-linked R176Q mutation.

DOI

10.1016/j.hrthm.2017.12.017

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