Abridging the 22-Item Sino-Nasal Outcome Test (SNOT-22) in People with Cystic Fibrosis: Limiting Survey Burden

Authors

Haidee Chen, University of California Los Angeles
Jakob L. Fischer, University of California Los Angeles
Tristan D. Tibbe, University of California Los Angeles
Ahmad R. Sedaghat, University of Cincinnati College of Medicine
Ethan J. Han, University of California Los Angeles
Jess C. Mace, Oregon Health & Science University
Jeremiah A. Alt, University of Utah
Todd E. Bodner, Portland State UniversityFollow
Naweed I. Chowdhury, Vanderbilt University Medical Center
Yuqing A. Gao, University of California Los Angeles
Peter H. Hwang, Stanford University
Ashoke Khanwalkar, University of Colorado
Adam J. Kimple, University of North Carolina
Jivianne T. Lee, University of California Los Angeles
Douglas A. Li, University of California Los Angeles
multiple additional authors

Sponsor

This work was supported by the Cystic Fibrosis Foundation (BESWIC20A0 and BESWIC22Y5). This foundation provided support for the planning and execution of this work but did not have specific involvement in the study design, data collection, analysis, or interpretation, or decision to submit the article for publication. Research reported in this publication was supported by the National Center for Advancing Translational Science (NCATS) of the National Institutes of Health under the UCLA Clinical and Translational Science Institute grant number UL1TR001881. This material is based upon work supported by the National Science Foundation Graduate Research Fellowship Program under Grant No. DGE-2034835

Published In

International Forum of Allergy & Rhinology

Document Type

Article

Publication Date

5-15-2025

Subjects

Cystic fibrosis -- Quality of life, Olfactory disorders, Paranasal sinuses -- Diseases

Abstract

Chronic rhinosinusitis (CRS) affects quality-of-life (QoL) in people with cystic fibrosis (PwCF), despite the reduction in symptoms and symptom severity associated with cystic fibrosis transmembrane conductance regulator (CFTR) modulators [1]. To precisely assess sinus symptoms and treatment needs in the post-modulator period, patient-related QOL instruments should be revisited. The 22-item SinoNasal Outcome Test (SNOT-22) measures CRS burden and QoL. Abbreviated surveys can lessen respondent fatigue. Item response theory (IRT) can help refine surveys by identifying the most informative survey items while maintaining reliability [2–4]. IRT assesses item discrimination (ɑ), the ability to differentiate trait levels, and difficulty (β), which defines thresholds for response categories [2–4].

Rights

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

© 2025 The Author(s). International Forum of Allergy & Rhinology published by Wiley Periodicals LLC on behalf of American Academy of Otolaryngic Allergy and American Rhinologic Society.

DOI

10.1002/alr.23591

Persistent Identifier

https://archives.pdx.edu/ds/psu/43898

Publisher

Wiley

Citation Details

Chen, H., Fischer, J. L., Tibbe, T. D., Sedaghat, A. R., Han, E. J., Mace, J. C., Alt, J. A., Bodner, T. E., Chowdhury, N. I., Gao, Y. A., Hwang, P. H., Khanwalkar, A., Kimple, A. J., Lee, J. T., Li, D. A., Norris, M., Nayak, J. V., Collins, C., Patel, Z. M., … Beswick, D. M. (2025). Abridging the 22‐Item Sino‐Nasal Outcome Test (SNOT‐22) in People With Cystic Fibrosis: Limiting Survey Burden. International Forum of Allergy & Rhinology. Portico.