Publication Title

Journal of Clinical Microbiology

Document Type

Article

Publication Date

8-27-2018

Subjects

Neurocysticercosis -- Diagnosis -- Laboratory manuals, Epilepsy, Immunodiagnosis -- Laboratory manuals, Enzyme-linked immunosorbent assay, Antigens

Abstract

Neurocysticercosis accounts for approximately 30% of all epilepsy cases in most developing countries. The immunodiagnosis of cysticercosis is complex and strongly influenced by the course of infection, the disease burden, the cyst location, and the immune response of the host. The main approach to immunodiagnosis should thus be to evaluate whether the serological results are consistent with the diagnosis suggested by imaging. Antibody detection is performed using lentil lectin-purified parasite antigens in an enzyme-linked immunoelectrotransfer blot format, while antigen detection uses a monoclonal antibody-based enzyme-linked immunosorbent assay (ELISA). Promising new assay configurations have been developed for the detection of both antibody and antigen, including assays based on synthetic or recombinant antigens that may reduce costs and improve assay reproducibility and multiplex bead-based assays that may provide simultaneous quantitative results for several target antigens or antibodies.

Description

© 2018 American Society for Microbiology.

"This work was authored as part of the Contributor's official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law."

DOI

10.1128/JCM.00424-18

Persistent Identifier

https://archives.pdx.edu/ds/psu/26988

Included in

Public Health Commons

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