This research was supported in part by grants from the Northwest Health Foundation and the Friends of Doernbecher.
Intracranial pressure, Biology -- Research, Brain Concussion
See additional files below for the Presentation.
We describe a computer model of intracranial pressure (ICP) dynamics that evaluates clinical treatment options for elevated ICP during traumatic brain injury (TBI). The model uses fluid volumes as primary state variables and explicitly models fluid flows as well as the resistance, compliance, and pressure associated with each intra - and extracranial compartment (arteries and arterioles, capillary bed, veins, venous sinus, ventricles, and brain parenchyma). The model evaluates clinical events and therapies such as intra - and extra-parenchymal hemorrhage, cerebral edema, cerebrospinal fluid drainage, mannitol administration, head elevation, and mild hyperventilation. The model is able to replicate observed clinical behavior in many cases, including elevated ICP associated with severe cerebral edema following subdural, epidural, or intraparynchemal hematoma. The model also mimics cerebrovascular regulatory mechanisms that are activated during TBI.
Wakeland, W., McNames, J., Aboy, M., Hollemon, D., & Goldstein, B. (2003, September). Modeling intracranial fluid flows and volumes during traumatic brain injury to better understand pressure dynamics. In Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE (Vol. 1, pp. 402-405). IEEE.