This work was supported in part by the Thrasher Research Fund
Intracranial pressure, Biology -- Research, Brain Concussion
We describe the calibration of a computer model of intracranial pressure (ICP) dynamics to correspond with annotated clinical data taken from a patient being treated for elevated ICP due to a traumatic brain injury. The research protocol employed during treatment includes adjusting the elevation of the head of the bed, adjusting the ventilator settings to induce mild hyperventilation and hypoventilation, and adjusting the height of the cerebrospinal fluid drainage system. The model behavior corresponds to the experimental data quite well in the case of the changing the head of the bed, but less well in the case of changing the ventilator settings.
Wakeland, W., Goldstein, B., and McNames, J. Calibrating an Intracranial Pressure Dynamics Model with Annotated Clinical Data--a Progress Report. Presented at the 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2004 in San Francisco, California.