Undergraduate Research & Mentoring Program
Advisor
Jun Jiao
Document Type
Poster
Publication Date
2016
Subjects
Cellular immunity, Cancer vaccines -- Development, Biomedical materials, Vaccines -- Biotechnology
Abstract
To meet the growing need for nanoengineered biocompatible materials to serve as drug delivery platforms, in this research, carbon nanotube arrays were fabricated by chemical vapor deposition, followed by an alumina coating by the high yielding, tightly controlled atomic layer deposition. This nanoengineered vertically aligned alumina nanowire array serves as a platform for delivering antigens, which act as cancer adjuvants. The physicochemical characteristics of the nanowires (NWs) can significantly influence the delivery of a biomolecule to immune cells. To investigate the material characteristics, the delivery efficiency of the antigen using NWs was quantitatively assessed by flow cytometry. Further, the mechanism through which the NWS deliver the antigen and trigger cellular pathways was investigated using various fluorophores and imaged with confocal microscopy.
Persistent Identifier
http://archives.pdx.edu/ds/psu/17820
Citation Details
Aier, Shree, "Quantitative Comparison of a Nanoengineered Alumina Coated CNT Arrays to SiO2 Coated CNTs and Solution Based Delivery System" (2016). Undergraduate Research & Mentoring Program. 5.
http://archives.pdx.edu/ds/psu/17820
Project Abstract
Included in
Biochemistry Commons, Molecular Biology Commons, Molecular, Cellular, and Tissue Engineering Commons
Description
The project abstract is located below in Additional Files