Earlier Diagnosis Not Self-Evidently Beneficial: Natural History of Subcentimeter Lung Cancers
American Journal Of Roentgenology
OBJECTIVE. We estimated the natural history of subcentimeter stage I non–small cell lung cancers detected on screening CT using a computed mean 230-day tumor volume doubling time and exponential growth.
CONCLUSION. We found that the majority of patients with subcentimeter, non–small cell lung cancers would survive for more than 5 years without treatment. The benefit of cancer interdiction would be offset to some extent by the combined effects of surgical mortality and materially diminished longer-term disease-free survival among the more than 40% of patients who would be overdiagnosed.
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American Roentgen Ray Society, ARRS
Reich, J. M., & Kim, J. S. (2019). Earlier Diagnosis Not Self-Evidently Beneficial: Natural History of Subcentimeter Lung Cancers. AJR. American Journal Of Roentgenology, 1–2.