Presenter Biography
Saifullah Hasan is a second year medical student at the Oregon Health and Science University.
Institution
OHSU
Program/Major
School of Medicine
Degree
MD
Presentation Type
Poster
Room Location
Smith Memorial Student Union, Room 296/8
Start Date
April 2019
End Date
April 2019
Persistent Identifier
https://archives.pdx.edu/ds/psu/30960
Abstract
Heart transplantation offers the best prognostic results for patients with end stage heart failure. However, there is a much greater demand for donor hearts than there is adequate supply. Cold static storage (CSS) is the current standard protocol for donor heart procurement. CSS has excellent prognosis but subjects the organ to ischemic reperfusion injury (IRI) and induces tissue inflammation due to anoxic conditions and oxidative stress. Hearts from older donors or patients that have a history of previous heart disease can’t withstand the anoxic stressors and make for poor donor candidates with the CSS protocol since they are associated with worse prognostic outcomes, which restricts the donor pool for acceptable hearts. Ex vivo heart perfusion, a novel method for heart transport, is a potential solution to expanding the donor pool and reducing the IRI and anoxic insults. This protocol continuously perfuses the donor heart and has been shown to reduce ischemic injury, increase ex vivo viability time and improve the biochemical and cellular profile of the donor heart. These factors collectively open the door for the possibility of expanding the acceptable pool of donor hearts since this protocol places fewer stressors on the myocardial tissue. We review the limitations of the cold static storage protocol and evaluate the benefits, drawbacks and practicality of the ex vivo heart perfusion for use in clinical practice by examining both human and animal studies.
Included in
Ex Vivo Heart Perfusion
Smith Memorial Student Union, Room 296/8
Heart transplantation offers the best prognostic results for patients with end stage heart failure. However, there is a much greater demand for donor hearts than there is adequate supply. Cold static storage (CSS) is the current standard protocol for donor heart procurement. CSS has excellent prognosis but subjects the organ to ischemic reperfusion injury (IRI) and induces tissue inflammation due to anoxic conditions and oxidative stress. Hearts from older donors or patients that have a history of previous heart disease can’t withstand the anoxic stressors and make for poor donor candidates with the CSS protocol since they are associated with worse prognostic outcomes, which restricts the donor pool for acceptable hearts. Ex vivo heart perfusion, a novel method for heart transport, is a potential solution to expanding the donor pool and reducing the IRI and anoxic insults. This protocol continuously perfuses the donor heart and has been shown to reduce ischemic injury, increase ex vivo viability time and improve the biochemical and cellular profile of the donor heart. These factors collectively open the door for the possibility of expanding the acceptable pool of donor hearts since this protocol places fewer stressors on the myocardial tissue. We review the limitations of the cold static storage protocol and evaluate the benefits, drawbacks and practicality of the ex vivo heart perfusion for use in clinical practice by examining both human and animal studies.