First Advisor
Hyunjee Kim
Date of Award
Fall 12-1-2023
Document Type
Thesis
Degree Name
Bachelor of Science (B.S.) in Biology and University Honors
Department
Biology
Language
English
Subjects
Breast Cancer, Population-Based Testing, Next Generation Sequencing (NGS), Myriad, Economic Evaluation
DOI
10.15760/honors.1455
Abstract
Breast cancer develops due to accumulated DNA replication insults which causes cancer to uncontrollably proliferate. An individual's predisposition to developing cancer, as well as the composition of a tumor, can be sequenced using genetic tests. Myriad's BRACAnalysis CDx® seems to be the most utilized genetic test. However, Next Generation Sequencing (NGS) seems to be a better genetic test for breast cancer when compared to Myriad's BRACAnalysisCDx® in terms of return-time, accuracy, efficiency, and healthcare cost. By using Next Generation Sequencing tests, stakeholders can save money on genetic testing which can be invested in more genetic tests. Payers can also save money by establishing a population-based testing strategy for breast cancer as compared to the family-history/clinical history-based distribution currently in place in America to reduce preventable deaths. There was found to be a large disparity between breast cancer emergence and survival rates between Black individuals and White individuals. To best address this disparity in the interest of equality, programs should use a population-based method of dispersal of NGS tests for breast cancer.
Persistent Identifier
https://archives.pdx.edu/ds/psu/41378
Recommended Citation
Curelaru, Sapphire, "Economic Analysis of Population-Based Next Generation Sequencing for Breast Cancer" (2023). University Honors Theses. Paper 1424.
https://doi.org/10.15760/honors.1455
Included in
Economic Policy Commons, Health Policy Commons, Inequality and Stratification Commons, Medicine and Health Commons, Public Administration Commons, Public Policy Commons, Quality Improvement Commons, Race and Ethnicity Commons
Comments
An undergraduate thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Arts/Science in University Honors and Biology.