Date of Award
Sarcoplasmic reticulum, Biological transport, Nanoparticles -- Effect on water transport across skeletal muscle
This thesis investigated the effects of mercaptocarborane-capped gold nanoparticles on water transport across skeletal muscle sarcoplasmic reticulum (SR). Data suggest that as the concentration of these gold nanoparticles increase, they cause a decrease in the initial rate of water transport, a decrease in the amount of water released from SR vesicles, and a decrease in the rate constant associated with water transport across the SR. Gold nanoparticles likely produce these effects by altering the behavior of the lipids on the SR membrane, causing them to be less permeable to water transport. The mechanism behind this isn’t known and would be an interesting subject to investigate further.
Bohlen, Jerry K. Jr., "The Effects of Mercaptocarborane-capped Gold Nanoparticles on Water Transport across Skeletal Muscle Sarcoplasmic Reticulum" (2017). University Honors Theses. Paper 379.