Date of Award

2017

Document Type

Thesis

Department

Biology

First Advisor

Jonathon Abramson

Subjects

Sarcoplasmic reticulum, Biological transport, Nanoparticles -- Effect on water transport across skeletal muscle

DOI

10.15760/honors.377

Abstract

This thesis investigated the effects of mercaptocarborane-capped gold nanoparticles on water transport across skeletal muscle sarcoplasmic reticulum (SR). Data suggest that as the concentration of these gold nanoparticles increase, they cause a decrease in the initial rate of water transport, a decrease in the amount of water released from SR vesicles, and a decrease in the rate constant associated with water transport across the SR. Gold nanoparticles likely produce these effects by altering the behavior of the lipids on the SR membrane, causing them to be less permeable to water transport. The mechanism behind this isn’t known and would be an interesting subject to investigate further.

Comments

An undergraduate honors thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in University Honors and Biology.

Persistent Identifier

http://archives.pdx.edu/ds/psu/20268

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