Published In
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Document Type
Post-Print
Publication Date
5-14-2024
Subjects
Antibiotic Exposure -- risk factors
Abstract
Antibiotics are a strong risk factor for Clostridioides difficile infection (CDI), and CDI incidence is often measured as an important outcome metric for antimicrobial stewardship interventions aiming to reduce antibiotic use. However, risk of CDI from antibiotics varies by agent and dependent on the intensity (i.e., spectrum and duration) of antibiotic therapy. Thus, the impact of stewardship interventions on CDI incidence is variable, and understanding this risk requires a more granular measure of intensity of therapy than traditionally used measures like days of therapy (DOT).
Rights
© Copyright the author(s) 2024
Locate the Document
DOI
10.1093/cid/ciae259
Persistent Identifier
https://archives.pdx.edu/ds/psu/41834
Citation Details
Published as: Ray, M. J., Strnad, L. C., Tucker, K. J., Furuno, J. P., Lofgren, E. T., McCracken, C. M., Park, H., Gerber, J. S., & McGregor, J. C. (2024). Influence of Antibiotic Exposure Intensity on the Risk of Clostridioides difficile Infection. Clinical Infectious Diseases.
Description
This is the author’s version of a work that was accepted for publication. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published as: Ray, M. J., Strnad, L. C., Tucker, K. J., Furuno, J. P., Lofgren, E. T., McCracken, C. M., ... & McGregor, J. C. (2024). Influence of Antibiotic Exposure Intensity on the Risk of Clostridioides difficile Infection. Clinical Infectious Diseases, ciae259.