Modeling Intracranial Fluid Flows and Volumes During Traumatic Brain Injury to Better Understand Pressure Dynamics

Authors

Wayne W. Wakeland, Portland State UniversityFollow
James McNames, Portland State UniversityFollow
Mateo Aboy, Portland State UniversityFollow
D. Hollemon, Oregon Health & Science University
Brahm Goldstein, Oregon Health & Science UniversityFollow

Sponsor

This research was supported in part by grants from the Northwest Health Foundation and the Friends of Doernbecher.

Document Type

Post-Print

Publication Date

2003

Subjects

Intracranial pressure, Biology -- Research, Brain Concussion

Abstract

See additional files below for the Presentation.

We describe a computer model of intracranial pressure (ICP) dynamics that evaluates clinical treatment options for elevated ICP during traumatic brain injury (TBI). The model uses fluid volumes as primary state variables and explicitly models fluid flows as well as the resistance, compliance, and pressure associated with each intra - and extracranial compartment (arteries and arterioles, capillary bed, veins, venous sinus, ventricles, and brain parenchyma). The model evaluates clinical events and therapies such as intra - and extra-parenchymal hemorrhage, cerebral edema, cerebrospinal fluid drainage, mannitol administration, head elevation, and mild hyperventilation. The model is able to replicate observed clinical behavior in many cases, including elevated ICP associated with severe cerebral edema following subdural, epidural, or intraparynchemal hematoma. The model also mimics cerebrovascular regulatory mechanisms that are activated during TBI.

Description

This is the authors version of an article accepted for publication. © 2003 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.

The definitive version can be found at the publishers site. https://doi.org/10.1109/IEMBS.2003.1279687

See the additional files below for accompanying Presentation.

DOI

10.1109/IEMBS.2003.1279687

Persistent Identifier

http://archives.pdx.edu/ds/psu/17764

Citation Details

Wakeland, W., McNames, J., Aboy, M., Hollemon, D., & Goldstein, B. (2003, September). Modeling intracranial fluid flows and volumes during traumatic brain injury to better understand pressure dynamics. In Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE (Vol. 1, pp. 402-405). IEEE.