This project was supported by the National Science Foundation [MCB1817993 to SE and MCB-1817762 to VK and UB], and by an American Heart Assoc. predoc Fellowship [23PRE899291] and a Portland State University Forbes-Lea Award to ZPD.
Current Opinion in Genetics & Development
Genomes -- research, Nematodes
Aided by new technologies, the upsurgence of research into mitochondrial genome biology during the past 15 years suggests that we have misunderstood, and perhaps dramatically underestimated, the ongoing biological and evolutionary significance of our long-time symbiotic partner. While we have begun to scratch the surface of several topics, many questions regarding the nature of mutation and selection in the mitochondrial genome, and the nature of its relationship to the nuclear genome, remain unanswered. Although best known for their contributions to studies of developmental and aging biology, Caenorhabditis nematodes are increasingly recognized as excellent model systems to advance understanding in these areas. We review recent discoveries with relevance to mitonuclear coevolution and conflict and offer several fertile areas for future work.
© 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).
Locate the Document
Estes, S., Dietz, Z. P., Katju, V., & Bergthorsson, U. (2023). Evolutionary codependency: insights into the mitonuclear interaction landscape from experimental and wild Caenorhabditis nematodes. Current Opinion in Genetics & Development, 81, 102081.