The authors acknowledge grant support from the National Institutes of Health (Grant EB-11687 to M.W.; Grants RR-02584 and CA-115531 to A.D.S.), the Oregon Nanoscience and Microtechnology Institute, the Oregon Opportunity partnership for advancing biomedical research, the M. J. Murdock Charitable Trust, and the Robert A. Welch Foundation (Grant AT-584).
Lanthanide shift reagents, Chelates -- Synthesis, Contrast media (Diagnostic imaging), Magnetic resonance imaging
The square antiprism/twisted square antiprism ratio in LnDOTA-tetraamide chelates is a critical parameter in governing water-exchange kinetics and ultimately the utility of a chelate as a PARACEST MRI contrast agent. In LnDOTA-tetraamide chelates with tertiary amides, this ratio and the rate of interconversion between these two structural isomers are found to be dramatically dependent upon the solvent and possibly other local environmental factors.
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Published as: Miller, K. J., Saherwala, A. A., Webber, B. C., Wu, Y., Sherry, A. D., & Woods, M. (2010). The population of SAP and TSAP isomers in cyclen-based lanthanide(III) chelates is substantially affected by solvent. Inorganic chemistry, 49(19), 8662–8664. https://doi.org/10.1021/ic101489t