Sponsor
The authors acknowledge grant support from the National Institutes of Health (Grant EB-11687 to M.W.; Grants RR-02584 and CA-115531 to A.D.S.), the Oregon Nanoscience and Microtechnology Institute, the Oregon Opportunity partnership for advancing biomedical research, the M. J. Murdock Charitable Trust, and the Robert A. Welch Foundation (Grant AT-584).
Published In
Inorganic Chemistry
Document Type
Post-Print
Publication Date
2010
Subjects
Lanthanide shift reagents, Chelates -- Synthesis, Contrast media (Diagnostic imaging), Magnetic resonance imaging
Abstract
The square antiprism/twisted square antiprism ratio in LnDOTA-tetraamide chelates is a critical parameter in governing water-exchange kinetics and ultimately the utility of a chelate as a PARACEST MRI contrast agent. In LnDOTA-tetraamide chelates with tertiary amides, this ratio and the rate of interconversion between these two structural isomers are found to be dramatically dependent upon the solvent and possibly other local environmental factors.
Locate the Document
DOI
10.1021/ic101489t
Persistent Identifier
https://archives.pdx.edu/ds/psu/32393
Citation Details
Published as: Miller, K. J., Saherwala, A. A., Webber, B. C., Wu, Y., Sherry, A. D., & Woods, M. (2010). The population of SAP and TSAP isomers in cyclen-based lanthanide(III) chelates is substantially affected by solvent. Inorganic chemistry, 49(19), 8662–8664. https://doi.org/10.1021/ic101489t
Supplementary Materials
Description
This is the author’s version of a work that was accepted for publication in Inorganic Chemistry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Inorganic Chemistry, 2010, 49, 19, 8662-8664
Copyright © 2010 American Chemical Society