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Acta Radiologica

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Paramagnetic contrast media, Contrast-enhanced magnetic resonance imaging, Contrast media (Diagnostic imaging), Magnetic resonance imaging


In this review we describe the status of development for a new class of magnetic resonance (MR) contrast agents, based on chemical exchange saturation transfer (CEST). The mathematics and physics relevant to the description of the CEST effect in MR are presented in an appendix published in the online version only. We discuss the issues arising when translating in vitro results obtained with CEST agents to using these MR agents in in vivo model studies and in humans. Examples are given on how these agents are imaged in vivo. We summarize the status of development of these CEST agents, and speculate about the next steps that may be taken towards the demonstration of CEST MR imaging in clinical applications.


This is the author’s version of a work that was accepted for publication in Acta Radiologica. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Acta Radiologica, 2010 Oct;51(8):910-23. doi: 10.3109/02841851.2010.502126.



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