Title

Aryl(tmp)iodonium Tosylate Reagents As a Strategic Entry Point to Diverse Aryl Intermediates: Selective Access to Arynes.

Published In

Organic Letters

Document Type

Citation

Publication Date

5-25-2021

Abstract

Arenes are broadly found motifs in societally important molecules. Access to diverse arene chemical space is critically important, and the ability to do so from common reagents is highly desirable. Aryl(TMP)iodonium tosylates provide one such access point to arene chemical space via diverse aryl intermediates. Here we demonstrate that controlling reaction pathways selectively leads to arynes with a broad scope of arenes and arynophiles (24 examples, 70% average yield) and efficient access to biologically active compounds.

Rights

© 2021 American Chemical Society

DOI

10.1021/acs.orglett.1c01534

Persistent Identifier

https://archives.pdx.edu/ds/psu/35649

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