Paramagnetic Lanthanide Complexes as PARACEST Agents for Medical Imaging

Authors

Mark Woods, Portland State UniversityFollow
Donald E. Woessner, University of Texas Southwestern Medical Center
A. Dean Sherry, University of Texas Southwestern Medical CenterFollow

Published In

Chemical Society Reviews

Document Type

Citation

Publication Date

2006

Abstract

This tutorial review examines the fundamental aspects of a new class of contrast media for MRI based upon the chemical shift saturation transfer (CEST) mechanism. Several paramagnetic versions called PARACEST agents have shown utility as responsive agents for reporting physiological or metabolic information by MRI. It is shown that basic NMR exchange theory can be used to predict how parameters such as chemical shift, bound water lifetimes, and relaxation rates can be optimized to maximize the sensitivity of PARACEST agents.

Rights

© The Royal Society of Chemistry 2006

Locate the Document

10.1039/B509907M

DOI

10.1039/B509907M

Persistent Identifier

https://archives.pdx.edu/ds/psu/36465

Citation Details

Woods, M., Woessner, D. E., & Sherry, A. D. (2006). Paramagnetic lanthanide complexes as PARACEST agents for medical imaging. Chemical Society Reviews, 35(6), 500-511.