Thomas V. Hancock
Date of Award
Bachelor of Science (B.S.) in Biology and University Honors
Skeletal muscle has an innate ability to self-regenerate in response to certain stimuli. In the case of trauma, muscle resident stem cells are required to meet the regenerative needs of the tissue. These resident stem cells, called satellite cells (SCs), are crucial in the regenerative process following injury; understanding the major factors which regulate satellite cell activity can provide valuable insight for regenerative medicine. The ability to implement and properly activate satellite cells has immense potential in the treatment of conditions including trauma, degenerative disorders, and age-related sarcopenia. This review will discuss the current understanding of satellite cell-mediated regeneration and the related cellular and molecular dynamics involved in regulation. Lastly, current research in this area of regenerative medicine and implications for future clinical applications will be explored.
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Vlasman, Sydney M., "Roles and Regulation of Satellite Cells in Skeletal Muscle Regeneration" (2021). University Honors Theses. Paper 1109.
Cell Biology Commons, Medical Cell Biology Commons, Medical Physiology Commons, Musculoskeletal, Neural, and Ocular Physiology Commons, Other Medical Sciences Commons, Physiotherapy Commons, Trauma Commons