First Advisor

Claire Wheeler

Date of Award


Document Type


Degree Name

Bachelor of Science (B.S.) in Public Health Studies: Pre-clinical Health Science and University Honors


OHSU-PSU School of Public Health




gut-brain axis, Alzheimer’s Disease, psychobiotics, fecal microbial transplantation, blood-brain barrier, neuroinflammation




The importance of the gut microbiome in health has become increasingly recognized as more research points to the strong association between an imbalanced gut microbial composition and a diseased state. Alzheimer's Disease burdens millions, and the rate of growth is expected to increase. However, current treatment methods are less than ideal and do not offer a substantial benefit to patients' quality of life. Additionally, there are gaps in the current understanding of Alzheimer's Disease pathogenesis. Research on the relationship between gut microbiota and neurodegeneration provides a different perspective on the pathogenesis and treatment methods for dementia, such as Alzheimer's Disease. This review aims to discuss the main mechanisms of gut-microbiota brain communication, how an altered gut microbial composition can lead to neuroinflammation and neurodegeneration, as well as microbiome targeted therapies for Alzheimer's Disease such as probiotics and fecal microbial transplantation.


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