Date of Award
Bachelor of Science (B.S.) in Biology and University Honors
Migraine, calcitonin gene-related peptide (CGRP), transient receptor potential ankyrin-1 (TRPA-1), behavioral changes, serotonin, chronobiology
Migraine headache is a physiologically complex disorder that presents as an intense headache with other symptoms. Globally, more than one billion people suffer from migraine, and it is the second leading cause of disability worldwide. At present, migraines are targeted with many pharmaceutical interventions; however, there are no well-studied ways to combat migraines through lifestyle modifications alone. One of the molecules involved in migraine physiology is the calcitonin gene-related peptide (CGRP), which causes vasodilation and the sensation of pain. The focus of this thesis is to find connections between CGRP physiology and modifiable factors that individuals have the power and autonomy to change. This thesis explores the connections between migraine and the TRPA-1 receptor, serotonin, sleep patterns, melatonin, exercise, caffeine, and a variety of nutrients. Several modifiable lifestyle factors and behaviors are identified including changes to diet, physical activity, and sleep patterns to decrease the frequency and severity of migraine attacks.
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Kogan, Sophia A., "Connection Between Migraine Physiology and Modifiable Lifestyle Factors and Behaviors: A Literature Review" (2023). University Honors Theses. Paper 1303.
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