First Advisor

Claire Wheeler

Date of Award


Document Type


Degree Name

Bachelor of Science (B.S.) in Biology and University Honors






Calcitonin gene-related peptide -- Physiological effect, Migraine -- Prevention, Human behavior




Migraine headache is a physiologically complex disorder that presents as an intense headache with other symptoms. Globally, more than one billion people suffer from migraine, and it is the second leading cause of disability worldwide. At present, migraines are targeted with many pharmaceutical interventions; however, there are no well-studied ways to combat migraines through lifestyle modifications alone. One of the molecules involved in migraine physiology is the calcitonin gene-related peptide (CGRP), which causes vasodilation and the sensation of pain. The focus of this thesis is to find connections between CGRP physiology and modifiable factors that individuals have the power and autonomy to change. This thesis explores the connections between migraine and the TRPA-1 receptor, serotonin, sleep patterns, melatonin, exercise, caffeine, and a variety of nutrients. Several modifiable lifestyle factors and behaviors are identified including changes to diet, physical activity, and sleep patterns to decrease the frequency and severity of migraine attacks.


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An undergraduate honors thesis submitted in partial fulfillment of the requirements for the degrees of Bachelor of Science in University Honors and Biology, and Bachelor of Arts in University Honors and Public Health Studies: Pre-Clinical Health Science

Persistent Identifier

Available for download on Saturday, May 24, 2025