Date of Award
Bachelor of Science (B.S.) in Biology and University Honors
B cells, Lymphocytes, Cell receptors
Malignant B-cell lymphocytes in chronic lymphocytic leukemia are supported by a network of survival signals from the bone marrow and lymph node microenvironments. These induce resistance to existing therapies such as inhibitors of B-cell receptor (BCR)-associated kinases, possibly due to the circumvention of BCRs to induce the same survival responses. It has been demonstrated that downstream responses to BCR stimulation can be induced through B-cell activating factor (BAFF) stimulation. Here, a mechanism for this pathway is proposed.
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Sreekantham, Bhargava, "Mechanistic Elements of BAFF-BCR Crosstalk in Chronic Lymphocytic Leukemia" (2017). University Honors Theses. Paper 414.