Date of Award
B cells, Lymphocytes, Cell receptors
Malignant B-cell lymphocytes in chronic lymphocytic leukemia are supported by a network of survival signals from the bone marrow and lymph node microenvironments. These induce resistance to existing therapies such as inhibitors of B-cell receptor (BCR)-associated kinases, possibly due to the circumvention of BCRs to induce the same survival responses. It has been demonstrated that downstream responses to BCR stimulation can be induced through B-cell activating factor (BAFF) stimulation. Here, a mechanism for this pathway is proposed.
Sreekantham, Bhargava, "Mechanistic Elements of BAFF-BCR Crosstalk in Chronic Lymphocytic Leukemia" (2017). University Honors Theses. Paper 414.