Date of Award

6-9-2017

Document Type

Thesis

Degree Name

Bachelor of Science (B.S.) in Biology and University Honors

Department

Biology

First Advisor

Alexey Danilov

Subjects

B cells, Lymphocytes, Cell receptors

DOI

10.15760/honors.407

Abstract

Malignant B-cell lymphocytes in chronic lymphocytic leukemia are supported by a network of survival signals from the bone marrow and lymph node microenvironments. These induce resistance to existing therapies such as inhibitors of B-cell receptor (BCR)-associated kinases, possibly due to the circumvention of BCRs to induce the same survival responses. It has been demonstrated that downstream responses to BCR stimulation can be induced through B-cell activating factor (BAFF) stimulation. Here, a mechanism for this pathway is proposed.

Persistent Identifier

http://archives.pdx.edu/ds/psu/20402

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