Published In
Proceedings of Spie--the International Society for Optical Engineering
Document Type
Pre-Print
Publication Date
2016
Subjects
Cerebellar ataxia -- magnetic resonance images, Atrophy pattern; shape analysis; landmarks; visualization; linear discriminant analysis; partial least squares
Abstract
Cerebellar dysfunction can lead to a wide range of movement disorders. Studying the cerebellar atrophy pattern associated with different cerebellar disease types can potentially help in diagnosis, prognosis, and treatment planning. In this paper, we present a landmark based shape analysis pipeline to classify healthy control and different ataxia types and to visualize the characteristic cerebellar atrophy patterns associated with different types. A highly informative feature representation of the cerebellar structure is constructed by extracting dense homologous landmarks on the boundary surfaces of cerebellar sub-structures. A diagnosis group classifier based on this representation is built using partial least square dimension reduction and regularized linear discriminant analysis. The characteristic atrophy pattern for an ataxia type is visualized by sampling along the discriminant direction between healthy controls and the ataxia type. Experimental results show that the proposed method can successfully classify healthy controls and different ataxia types. The visualized cerebellar atrophy patterns were consistent with the regional volume decreases observed in previous studies, but the proposed method provides intuitive and detailed understanding about changes of overall size and shape of the cerebellum, as well as that of individual lobules.
Rights
© Copyright the author(s) 2016
Persistent Identifier
https://archives.pdx.edu/ds/psu/44316
Citation Details
Published as: Yang, Z., Abulnaga, S. M., Carass, A., Kansal, K., Jedynak, B. M., Onyike, C., ... & Prince, J. L. (2016, March). Landmark based shape analysis for cerebellar ataxia classification and cerebellar atrophy pattern visualization. In Proceedings of Spie--the International Society for Optical Engineering (Vol. 9784, p. 97840P).
Description
This is the author’s version of a work that was accepted for publication. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published as: Landmark based shape analysis for cerebellar ataxia classification and cerebellar atrophy pattern visualization. In Proceedings of Spie--the International Society for Optical Engineering (Vol. 9784, p. 97840P).