First Advisor

David T. Clark

Term of Graduation

1979

Date of Publication

1979

Document Type

Thesis

Degree Name

Master of Science (M.S.) in Biology

Department

Biology

Language

English

Subjects

Aging, Vitamin C, Lipids

DOI

10.15760/etd.2896

Physical Description

1 online resource (2, vi, 62 pages)

Abstract

The role of ascorbic acid with regard to lipid peroxidation and aging has been examined. A thorough literature analysis indicates that free radical-induced lipid peroxidation is a plausible biochemical explanation for aging. Lipid peroxidation causes cellular damage due to altered enzyme activities, error-prone nucleic acid metabolism, and membrane dysfunction, as well as the accumulation of aging pigments in the lysomes. Ascorbic acid, a water soluble free radical quencher, was examined with regard to carbon tetra-chloride-induced lipid peroxidation and in vivo aging. Carbon tetrachloride, a well-known free radical inducer, caused marked increases in the ration of oxidized/reduced vitamin C only in the organs which metabolize carbon tetrachloride to the free radical form. Vitamin C treatment, 250 mg% in the drinking water, reduced the extent of carbon tetrachloride=induced lipid peroxidation. Aging is associated with marked increases in the ration of oxidized/reduced vitamin C in all organs examined with the exception of thymus. In organs exposed to high oxygen tensions, or in those exposed to high levels of free radicals, the ration of oxidized/reduced vitamin C exceeded the in vitro ration, indicating extensive lipid peroxidation. Vitamin C treatment reduced the extent of lipid peroxidation in vivo as determined by the ratio of oxidized/reduced vitamin C.

Rights

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Comments

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Persistent Identifier

http://archives.pdx.edu/ds/psu/17427

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