Advisor

Mary L. Taylor

Date of Award

1991

Document Type

Thesis

Degree Name

Master of Science (M.S.) in Biology

Department

Biology

Physical Description

1 online resource (69 p.)

Subjects

Conalbumin, Iron proteins -- Physiological effect, Salmonella, Bacteremia

Abstract

I have investigated the possibility that specific conalbumin (ovotransferrin) iron saturation levels enable less virulent strains of Salmonella to become more virulent. Iron starved cells of two pathogenic Salmonella strains, S. paratyphi B var. java and S. thompson, were cultured in iron limited media at 3 different iron conalbumin saturation levels. Results indicate that strains differ significantly at both low and high iron saturation conalbumin. These differences depict a growth advantage for S. paratyphi B which correlates with reports by the Centers for Disease Control that S. paratyphi B was 3 times more frequent in blood isolates than S. thompson. The ability to use protein bound iron may account for the higher involvement of S. paratyphi B in bacteremia.

Description

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