Work on this paper was supported by the National Human Genome Research Institute of the National Institutes of Health under Award Number R03HG010417.
Cambridge Quarterly of Healthcare Ethics
Gene editing -- Moral and ethical aspects, Genetic engineering, Bioethics, CRISPR (Genetics), Gene editing -- Applications to medicine
Since the advent of recombinant DNA technology, expectations (and trepidations) about the potential for altering genes and controlling our biology at the fundamental level have been sky high. These expectations have gone largely unfulfilled. But though the dream (or nightmare) of being able to control our biology is still far off, gene editing research has made enormous strides toward potential clinical use. This paper argues that when it comes to determining permissible uses of gene editing in one important medical context—germline intervention in reproductive medicine—issues about enhancement and eugenics are, for the foreseeable future, a red herring. Current translational goals for gene editing research involve a different kind of editing than would be required to achieve manipulation of complex traits such as intelligence, and there are more pressing (and unresolved) questions that need attention if clinical use of gene editing in reproductive medicine ever becomes a possibility.
Cwik, Bryan, "Moving Beyond ‘Therapy’ and ‘Enhancement’ in the Ethics of Gene Editing" (2019). Philosophy Faculty Publications and Presentations. 51.