Characterization of Retinol Stabilized in Phosphatidylcholine Vesicles With and Without Antioxidants

Authors

Yekaterina G. Chmykh, Portland State University
Jay Nadeau, Portland State UniversityFollow

Published In

ACS Omega

Document Type

Article

Publication Date

2020

Subjects

Retinol -- Research -- Clinical trails

Abstract

Retinol stability has been reported to be improved by encapsulation in liposomes, both with and without cholesterol. However, this improvement is limited because of lipid peroxidation. In this study, we compare the stability of retinol in phosphatidylcholine liposomes under ultraviolet (UV) light or standard room air, with and without the addition of antioxidants. Both butylated hydroxytoluene (BHT) and a proprietary mix (StoppOx) improved the shelf stability from vesicles, including within the aqueous layer. Fluorescence lifetimes were equally heterogeneous. Under UV irradiation, StoppOx protected retinol for significantly longer than BHT and via different mechanisms. This suggests that natural antioxidants work well to improve the retinol stability, but that further work to determine the optimal vesicle structure remains to be performed.

Description

Copyright (c) 2020 The Authors

This work is licensed under a Creative Commons Attribution 4.0 International License.

Locate the Document

https://doi-org/10.1021/acsomega.0c02102

DOI

10.1021/acsomega.0c02102

Persistent Identifier

https://archives.pdx.edu/ds/psu/34028

Citation Details

Chmykh, Y. G., & Nadeau, J. L. (2020). Characterization of Retinol Stabilized in Phosphatidylcholine Vesicles with and without Antioxidants. ACS omega, 5(29), 18367-18375.