Sponsor
The authors acknowledge the support of the National Science Foundation Grant Number 1828793. Portions of this work were supported under a contract from the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration.
Published In
Microgravity
Document Type
Article
Publication Date
2-2021
Subjects
Motility -- Microorganisms, Microgravity -- Spaceflight
Abstract
As interest in space exploration rises, there is a growing need to quantify the impact of microgravity on the growth, survival, and adaptation of microorganisms, including those responsible for astronaut illness. Motility is a key microbial behavior that plays important roles in nutrient assimilation, tissue localization and invasion, pathogenicity, biofilm formation, and ultimately survival. Very few studies have specifically looked at the effects of microgravity on the phenotypes of microbial motility. However, genomic and transcriptomic studies give a broad general picture of overall gene expression that can be used to predict motility phenotypes based upon selected genes, such as those responsible for flagellar synthesis and function and/or taxis. In this review, we focus on specific strains of Gram-negative bacteria that have been the most studied in this context. We begin with a discussion of Earth-based microgravity simulation systems and how they may affect the genes and phenotypes of interest. We then summarize results from both Earth- and space-based systems showing effects of microgravity on motility-related genes and phenotypes.
Rights
Copyright (c) 2021 The Authors
This work is licensed under a Creative Commons Attribution 4.0 International License.
Locate the Document
DOI
10.1038/s41526-021-00135-x
Persistent Identifier
https://archives.pdx.edu/ds/psu/35113
Citation Details
Acres, J.M., Youngapelian, M.J. & Nadeau, J. The influence of spaceflight and simulated microgravity on bacterial motility and chemotaxis. npj Microgravity 7, 7 (2021). https://doi-org.proxy.lib.pdx.edu/10.1038/s41526-021-00135-x